3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid
TTP 22
CAS: 329907-28-0
Molecular Formula: C16H14N2O2S2
3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid - Names and Identifiers
3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid - Physico-chemical Properties
| Molecular Formula | C16H14N2O2S2 |
| Molar Mass | 330.42 |
| Solubility | DMSO: ≥ 51 mg/mL |
| Storage Condition | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| In vitro study | TTP 22 is a potent CK2 inhibitor, with an IC 50 of 100 nM and a K i of 40 nM. TTP 22 shows no effect on other kianses such as Jnk3, Rock1, Tie2, Ask1, Met and FGFR1 at 10 μM. |
3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.026 ml | 15.132 ml | 30.264 ml |
| 5 mM | 0.605 ml | 3.026 ml | 6.053 ml |
| 10 mM | 0.303 ml | 1.513 ml | 3.026 ml |
| 5 mM | 0.061 ml | 0.303 ml | 0.605 ml |
Last Update：2024-01-02 23:10:35
3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid - Reference Information
| biological activity | TTP22 is a casein kinase 2 (CK2) inhibitor with an IC50 value of 100 nM. It is selective for CK2 and has no inhibitory activity for JNK3, ROCK1 and MET at a concentration of 10 μM. |
| target | TargetValue CK2 () 100 nM |
| Target | Value |
| CK2 () | 100 nM |
| in vitro study | TTP 22 is a potent CK2 inhibitor, with an IC 50 of 100 nM and a K I of 40 nM. TTP 22 shows no effect on other kianses such as Jnk3, Rock1, Tie2, Ask 1, met and FGFR1 at 10 μM. |
Last Update：2024-04-09 20:52:54
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View History
3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid
Phosphonothioic acid, P-phenyl-, O-(2,5-dichlorophenyl) O-methyl ester
3-[(4-Chloro-2-phosphonophenyl)azo]-4,5-dihydroxy-2,7-naphthalenedisulfonic acid
5-TRIFLUOROMETHYLINICOTINIC ACID
2-(9-Oxoxanthen-2-yl)propionic Acid 1,5-Diazabicyclo[4.3.0]non-5-ene Salt
2-([(DIMETHYLAMINO)METHYLENE]AMINO)-5-(4-METHOXYBENZOYL)-3-[2-(4-METHOXYPHENYL)-2-OXOETHYL]-1,3-THIAZOL-3-IUM BROMIDE
Phosphonothioic acid, P-phenyl-, O-(2,5-dichlorophenyl) O-methyl ester
3-[(4-Chloro-2-phosphonophenyl)azo]-4,5-dihydroxy-2,7-naphthalenedisulfonic acid
5-TRIFLUOROMETHYLINICOTINIC ACID
2-(9-Oxoxanthen-2-yl)propionic Acid 1,5-Diazabicyclo[4.3.0]non-5-ene Salt
2-([(DIMETHYLAMINO)METHYLENE]AMINO)-5-(4-METHOXYBENZOYL)-3-[2-(4-METHOXYPHENYL)-2-OXOETHYL]-1,3-THIAZOL-3-IUM BROMIDE